TcmSP

Systems pharmacology, an emerging discipline focused on identifying drug targets and exploring the underlying mechanisms of action of drugs, aims to develop formal mathematical and computational models that incorporate data at several temporal and spatial scales;

  • Evaluating oral bioavailability, drug-likeness, intestinal epithelial permeability and aqueous solubility
  • Identifying 3987 potential protein targets
  • Establishing interacting networks between herbal molecules and targets, and between targets and associated diseases
  • Working on a manually curated database of 31871 herbal compounds and 848 associated diseases

These models will focus on interactions among multiple elements (biomolecules, cells, tissues etc.) as a means to understand and predict therapeutic and toxic effects of drugs.

Creation of multi-scale models that ultimately span knowledge of molecules, cells, tissues and patients will be particularly critical for preclinical and clinical research teams evaluating target selection and testing therapeutic proof of concept.

Systems pharmacology draws on several existing disciplines, including classic pharmacology, chemical biology, biochemistry and structural biology, molecular genetics and genomics, pathology, applied mathematics, and medicine.

Systems pharmacology will accelerate drug discovery and development by helping to identify and validate targets (and druggable) networks, design better drugs and drug combinations, select appropriate doses and dosage regimens and identify those patients most likely to respond to new therapeutic agents and combinations.

It will therefore become a core discipline of traditional herbal medicine.

驱虫药
(Antiparasitic Drugs)
清热药
(Antipyretics)
收涩药
(Astringent Medicinal)
活血祛瘀药
(Blood Activating Stasis Removing Drugs)
化湿药
(Dampness Removing Drugs)
解表药
(Diaphoretics)
消食药
(Digestants)
利水渗湿药
(Diuretic Dampness Excreting Drugs)
通便逐水药
(Drastic Water-Expelling Medicinal)
涌吐药
(Emetic Medicinal)
化痰止咳平喘药
(Expectorant Antitussive Antiasthmetics)
拔毒化腐生肌药
(External Medicinal (Draw Out Toxin, Resolve Putridity))
止血药
(Hemostatic Medicinal)
平肝熄风药
(Liver-Pacifying Wind-Extinguishing Medicinal)
解毒杀虫燥湿止痒药
(Medicinal For Detoxification、Parasiticide、Drying Dampness And Relieving Itching)
理气药
(Qi Regulating Drugs)
开窍药
(Resuscitative Stimulant; Resuscitative Medicinal)
补虚药
(Tonifying Medicinal)
安神药
(Tranguilizing Medicinal)
温里药
(Warming Interior Drugs)
祛风湿药
(Wind Damp Dispelling Drugs)